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Endochondral ossification
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Endochondral ossification : ウィキペディア英語版
Endochondral ossification

Endochondral ossification〔Etymology from (ギリシア語:ἔνδον)/''endon'', "within", and χόνδρος/''chondros'', "cartilage"〕〔(【引用サイトリンク】 title = Etymology of the English word endochondral )〕 is one of the two essential processes during fetal development of the mammalian skeletal system by which bone tissue is created. Unlike intramembranous ossification, which is the other process by which bone tissue is created, cartilage is present during endochondral ossification. Endochondral ossification is also an essential process during the rudimentary formation of long bones,〔Netter, Frank H. (1987), ''Musculoskeletal system: anatomy, physiology, and metabolic disorders''. Summit, New Jersey: Ciba-Geigy Corporation ISBN 0-914168-88-6, p. 130: One exception is the clavicle.〕 the growth of the length of long bones,〔Brighton, Carl T., Yoichi Sugioka, and Robert M. Hunt (1973), "Cytoplasmic structures of epiphyseal plate chondrocytes; quantitative evaluation using electron micrographs of rat costochondral junctions with specific reference to the fate of hypertrophic cells", ''Journal of Bone and Joint Surgery'', 55-A: 771-784〕 and the natural healing of bone fractures.〔Brighton, Carl T. and Robert M. Hunt (1986): "Histochemical localization of calcium in the fracture callus with potassium pyroantimonate: possible role of chondrocyte mitochondrial calcium in callus calcification", ''Journal of Bone and Joint Surgery'', 68-A (5): 703-715〕
==Growth of the cartilage model==
The cartilage model will grow in length by continuous cell division of chondrocytes, which is accompanied by further secretion of extracellular matrix. This is called interstitial growth.
The process of appositional growth occurs when the cartilage model also grows in thickness due to the addition of more extracellular matrix on the peripheral cartilage surface, which is accompanied by new chondroblasts that develop from the perichondrium.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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